Xanthi will clash with holder Panathinaikos in the most appetizing of the eight ties for the round of 16 of the Greek Cup according to the draw conducted on Friday at the Hellenic Football Federation. When Xanthi hosted Panathinaikos last month it beat the Greens 4-2.
Olympiakos was fortunate enough to avoid any Super League opposition, and will face second-division team Tyrnavos, that hosts its home games at Larissa.
The other pairings are Panionios vs Veria, Panthrakikos vs OFI, Iraklis Thessaloniki vs Asteras Tripolis, Apollon Smyrnis vs Levadiakos, Hania vs PAS Giannina and Kerkyra vs AEK.
The home-and-away ties will be played on January 20-22 and 27-29. The final will take place at the Olympic Stadium of Athens on May 16.